Divide meat into 4 6 oz burgers patties.
Mix together onion powder, garlic powder, chili powder, salt and pepper.
Sprinkle seasoning mix on both sides of each patty.
Mix mayonnaise and picante sauce in a small bowl util well blended. Set aside.
Place on skillet and heat over medium heat for about 5 minutes (until lightly charred).
Flip and cook other side for about 5 minutes.
Place one slice of cheese on each burger and cover skillet until cheese melts.
Apply a think layer of picante mayonnaise to both sides of bun.
Dress bun with lettuce, tomato and onion (as desired).
Place patty on bottom bun and toppings.
Top patty with jalapeno slices.
Top with bun.